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    NIST CSWP 35, Cybersecurity Threat Modeling the Genomic Data Sequencing Workflow

    NIST initial public draft illustrating cybersecurity threat modeling for a genomic data sequencing and analysis workflow.

    Reviewed by Christian Espinosa, Founder, Blue Goat CyberLast reviewed June 20, 2026

    Definition

    NIST CSWP 35 initial public draft, Cybersecurity Threat Modeling the Genomic Data Sequencing Workflow: An example threat model implementation for genomic data sequencing and analysis, was published December 16, 2024. It illustrates threat modeling for genomic sequencing and analysis. It is not an HPH Cybersecurity Framework profile and is not NIST IR 8473.
    What the regulation says
    This is a NIST initial public draft, not binding law or a verified HHS-endorsed HPH implementation profile. NIST IR 8473 is instead an October 2023 electric-vehicle extreme-fast-charging profile based on CSF 1.1.

    What this means in practice

    Organizations handling genomic sequencing and analysis can use the example to inform workflow-specific threat modeling. Do not use it as an authoritative HIPAA, HICP, IEC 80001-1 or HPH-CPG crosswalk.

    Examples

    • Illustrative: A genomic laboratory reviews CSWP 35 draft examples when modeling its sequencing and analysis workflow.
    Common pitfalls
    • •Do not confuse CSWP 35 with IR 8473.
    • •Label the located CSWP 35 edition as an initial public draft, not a final standard.
    • •Do not infer healthcare regulatory crosswalks or compliance from a genomic workflow example.

    Frequently asked questions

    A December 16, 2024 initial public draft giving an example threat model for genomic sequencing and analysis.
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    Sources

    2 sources

    Sources support the definition or relevant regulatory context, not necessarily every claim on this page. Each is graded against our source-tier hierarchy so you can see what rests on binding law versus commentary.

    Official-source claim check:

    The merged entry misidentifies two unrelated NIST publications. CSWP 35 concerns genomic sequencing threat modeling; IR 8473 concerns EV extreme fast charging.

    Partial review: verified corrections are applied, but this is not a full accuracy certification. The last full review date is unchanged.

    Remaining verification limits
    • Located CSWP 35 initial draft and IR 8473 final publisher records. A later final CSWP 35 edition was not established; do not imply one.
    Tier 2Regulator guidance and consensus· 2
    Link health: 2 unchecked· last checked 2026-06-20
    1. 1
      NIST CSWP 35 initial draft
      Tier 2 Unchecked
      NISTcsrc.nist.gov
    2. 2
      NIST CSWP 35 PDF
      Tier 2 Unchecked
      NISTnvlpubs.nist.gov

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